This one has a bit of a twist so I can't really say what issue it deals with, but I can promise that it's a wonderful novel. I laughed and cried and didn't want to go to sleep last night because I was near the end. Her books remind me of something Dolly Parton says in Steel Magnolias about laughter through tears being the best emotion. I can't recall the direct quote.
This novel is in the series about the Walsh family, and Anna is the main character. The books aren't officially in order, but you'll find out the endings of Watermelon, Rachel's Holiday (her best novel in my opinion), and Angels if you read this one first.